Theo Vos was the son of a Carpenter from Groningen. He had his education at the Minerva Acadamy with Johan Peddemors and continued his study at the Académie des Beaux-Arts in Brussels in 1911-1912, with Victor Rousseau.
The following years he lived and worked in Paris, Cologne and settled in Holland again in 1916.
He was known for his mother-and-child figures, masks and animal sculpture. In 1924-1925 he designed figurines representing the famous dancer Gertrud Leistikow, that were partly executed in bronze in Holland, and, in white glazed porcelain, at the factory Hutschenreuther in Germany.
He made achitectural sculpture and reliëfs for Gerrit Jan Rutges, Willem Kromhout and other architects, for instance the series of ten façade sculptures for the extension of the American Hotel in Amsterdam.