During his career, which spanned six decades, Ponti built more than a hundred buildings in Italy and in the rest of the world. He designed a considerable number of decorative art and design objects as well as furniture. Thanks to the magazine Domus, which he founded in 1928 and directed almost all his life, and thanks to his active participation in exhibitions such as the Milan Triennial, he was also an enthusiastic advocate of an Italian-style art of living and a major player in the renewal of Italian design after World War II
His most famous works are the Pirelli Tower, built from 1956 to 1960 in Milan in collaboration with the engineer Pier Luigi Nervi, the Villa Planchart in Caracas and the Superleggera chair, produced by Cassina in 1957.
In 1923, Ponti was appointed artistic director of Richard Ginori, one of Italy's leading porcelain manufacturers, based in Milan and Sesto Fiorentino.